PSEN1 and Alzheimer disease: Their experiment showed: 6 months when the size of APP/PS1 mice were fed standard chow and add OLT1177 food after 3 months, can improve the learning and memory ability of mice, normalize AD metabolic markers in plasma, and restore the synaptic plasticity, reduce the number of pathological plaques in the cerebral cortex, and reducing the brain glial cell activity.