To further investigate the roles SPINT1 and SPINT2 jointly played in breast cancer, the common co-expressed genes were screened first by cross-referencing the respective top 500 correlated genes of SPINT1 and SPINT2 (ranking by the absolute value of Pearson correlation) (Table S3: Sheet 1, Sheet 2), and a total of 201 common co-expressed genes were obtained (Figure 8A and Table S4). This evidence concerns the gene SPINT1 and breast cancer.