By analyzing all 13 methylation sites of SPINT1 in breast cancer patients, we found three hypomethylated sites (TSS200; 5’-UTR-cg11701759, 3’-UTR-Open_Sea-cg04519327, and TSS200; 5’-UTR-Island-cg27510007) were significantly correlated with a poorer OS (Figures 6C–E). The gene discussed is SPINT1; the disease is breast cancer.