The Linkedomics results showed that SPINT1 and SPINT2 were reciprocally correlated in breast cancer (Pearson correlation = 0.437, P = 2.103e−52) (Figure S1G), which was close to the correlation statistics from cBioportal (TCGA, Firehose Legacy) (Pearson correlation = 0.42, P = 4.68e−83) (Figure S1H). The gene discussed is SPINT1; the disease is breast carcinoma.