A single nucleotide polymorphism in GUCY1A3, rs7692387, was associated with coronary artery disease at genome-wide significance, and it interferes with binding of the transcription factor ZEB1 and impairs GUCY1A3 expression, leading to lower sGC levels and lower sGC activity after stimulation (57). The gene discussed is GUCY1A1; the disease is coronary artery disorder.