It was reported that the causes of hyperlipidemia in hypothyroidism are the decreased expression of hepatic LDL receptors, which reduces cholesterol clearance, and the reduced activity of cholesterol-α-monooxygenase, an enzyme that breaks down cholesterol (Canaris et al., 2000; Jabbar et al., 2017). The gene discussed is LDLR; the disease is hyperlipidemia.