Therefore, our results demonstrate that L-THE significantly downregulates the production of IL-23 and chemokines, and alleviates the IMQ-induced psoriasis like skin inflammation by restraining the activation of NF‐κB and IL-17A signaling pathway, and promotes the propanoate metabolism, suggesting that L-THE can be used to treat psoriasis in clinical. Here, NFKB1 is linked to psoriasis.