Mineralocorticoid receptor (MR) signaling has a critical role in the fibrotic response observed in adverse cardiac remodeling (Brilla and Weber, 1992) treatment with MR antagonists (MRAs) resulted in a significant decrease in interstitial fibrosis and improved left ventricular function in rodents after permanent MI (Wang et al., 2004). Here, NR3C2 is linked to myocardial infarction.