CAMK2G and diabetes mellitus: An isoform-specific inhibitor of CaMKIIδ (the main cardiac isoform of CaMKII) could be utilized to target the cardiac-specific pathology of autonomously activated CaMKII in diabetes, avoiding any off-target effects in other tissues, such as the α and β isoforms of CaMKII and disruption of memory formation in the hippocampus (Buard et al., 2010).