Chronic activation of cardiac CaMKII is associated with increased myocyte apoptosis (Zhu et al., 2003), fibrosis (Luo et al., 2013), hypertrophy (Ljubojevic-Holzer et al., 2020) and heart failure (Hoch et al., 1999), all of which are also observed in animal models and clinical presentation of diabetes [for review, Murtaza et al. (2019)]. Here, CAMK2G is linked to heart failure.