CAMK2G and diabetes mellitus: Silberman et al. (2010) suggests that uncoupling of cardiac NOS mediates diastolic dysfunction. As previously discussed, NOS is known to be uncoupled in diabetes (Alp et al., 2003) leading to impaired NO production and increased levels of oxidative stress. Impairments in cardiac relaxation are a hallmark of diabetes (Fein et al., 1980; Lamberts et al., 2014; Daniels et al., 2018), so uncoupled NOS could be influencing modification of CaMKII by both nitrosylation and oxidation, contributing to the contractile dysfunction seen in diabetes.