However, nerigoside has been found to destroy the balance of proliferation and apoptosis through the ERK/GSK3β/β-catenin signaling pathways, whereas isobavachalcone exerts its anticancer effect via the AKT/GSK-3β/β-catenin pathway in CRC (Ashokkumar and Sudhandiran, 2011; Mervai et al. (2015); Qiu et al., 2017; Li et al., 2019; Tan et al., 2019; Wen et al., 2019). The gene discussed is GSK3B; the disease is colorectal carcinoma.