APC and colorectal carcinoma: The ethanol extract of Scutellaria barbata D. Don (EESB), used for the treatment of various types of cancer clinically (Wei et al., 2017; Zhang et al., 2017; Liu et al., 2018), has been found to prevent the development of human CRC via increasing APC expression with a concomitant decrease in the expression of ß-catenin, leading to inactivation of the Wnt/β-catenin pathway in a CRC xenografted mouse model and HT-29 cell line.