More importantly, GNE-477 has been reported to inactivate the PI3K-AKT-mTOR cascade by blocking the phosphorylation of p85, AKT1, p70S6K1 and S6, thereby inhibiting the growth of renal cell carcinoma in vitro and in vivo in nude mice (Ye et al., 2020). The gene discussed is AKT1; the disease is hereditary clear cell renal cell carcinoma.