In contrast, some SRCC-specific altered genes and signaling pathways were reported to be implicated in the “EMT” and “Stem Cell Up Regulation” processes (such as RNF43, CDH1, SMAD4, β-catenin and TGF-β pathway), which were believed the reason of the aggressive tumor biology and the chemoresistance of SRCC. The gene discussed is SMAD4; the disease is neoplasm.