Search terms included “signet ring cell”, “colorectal”, “colon”, “rectum”, “carcinoma”, “cancer”, “epidemiology”, “clinicopathological”, “molecular”, “genotype”, “mutation”, “microsatellite instability”, “BRAF”, “prognosis”, “survival”, “metastasis”, “surgery”, “chemotherapy”, and “treatment”. This evidence concerns the gene BRAF and cancer.