Autopsies of AD brain patients exhibited reactive microglia adjacent to Aβ plaques; this has been explicated that Aβ triggers several pathways such as the NF-κB-dependent pathway, mitogen-activated protein kinase (MAPK) pathways, the cell surface binding of microglia, and the initiation of extracellular signal-regulated kinase to stimulate proinflammatory gene expression [25, 45]. The gene discussed is WNK2; the disease is Alzheimer disease.