Following the accumulation of Aβ peptides, an immune reaction in the brain triggers the release and activity of inflammatory markers such as TNF-α, IL-1, IL-6, and the activation of specialized brain cells [168, 169] The inflammatory process takes place in the brain having dense and abridged pathologies of AD, though there are minor cases of inflammation in the brain regions with reduced AD pathologies [25]. This evidence concerns the gene TNF and Alzheimer disease.