NFKB1 and Alzheimer disease: Dysfunction of the CNS, oxidative stress, and neuroinflammation are the major events in AD which are activated and progress via activation of NF-κB. Generation of ROS triggers the IKKb enzyme which phosphorylates the heterodimer of NF-κB, an inhibitor of kappa B (IκB) causes its degradation by the ubiquitin-proteasome pathway, and the detachment of IκB from the dimer initiates the influx of NF-κB into the nucleus.