Case 1: PDGFRB c.3251_3256delCAGAGC P1084_E1085del (The PDGFRB in-frame deletion has been described both in normal individuals) (last accessed 07-04-2021 https://gnomad.broadinstitute.org/variant/5-149495390-AGCTCTG-A?dataset=exac) and in various cancer samples with unknown significance16. Here, PDGFRB is linked to cancer.