Next, we injected 2 × 107 CAR-T cells intravenously into the CRL5826-PD-L1 CDX model and obtained data consistent with our previous preclinical animal data (Fig. 1F and J), as the P4 and MTK-CAR-T cells inhibited tumor growth compared with the PBS control group, while MPK- and MPTK-CAR-T cell infusion almost cleared the tumor by day 36 (Fig. 6D). The gene discussed is CD274; the disease is neoplasm.