The VEGF network is involved in maintaining physiologic functioning of glomeruli and peritubular capillaries14,15 and has been found to be dysregulated in a large variety of kidney diseases including diabetic nephropathy, glomerulonephritis, thrombotic microangiopathies and chronic allograft nephropathy (CAN) after kidney transplantation14,15. The gene discussed is VEGFA; the disease is Crouzon syndrome-acanthosis nigricans syndrome.