First, we examined steady-state levels of rhodopsin in retinal protein lysates collected from Atf6+/−Rho+/P23H and Atf6−/−Rho+/P23H at P12, an age before morphological defects in photoreceptors or retinal degeneration emerges in Rho+/P23H mice22. The gene discussed is ATF6; the disease is retinal degeneration.