AFP and Cirrhosis: Univariate analysis showed that presence of hepatitis B/C virus infection, portal hypertension, Child–Pugh grade B liver function, AFP > 400 ng/mL, tumor size > 5 cm, major hepatectomy, intraoperative blood transfusion, moderate/severe cirrhosis, microvascular invasion, and moderate/poor tumor differentiation were associated with worse RFS (Table 3).