Moreover, to understand the effect of MS-275 in HDAC1 level, we evaluated the level of HDAC1 at 24 and 72 h after stroke, the data showed stroke induced a lower HDAC1 level comparing to sham rats (Fig. S2), whereas MS-275 did not significantly reduce HDAC1 level in rats with stroke. The gene discussed is HDAC1; the disease is Stroke.