The 65 conserved genes included commonly known decidualization genes such as SST, REN, MMP3, POSTN, PSAT1, and COL1A2, whereas the 19 DEGs included mostly genes related to cell cycle regulation: SPDYE16, FLT3, HDKC1, ACTG2, N4BP2, IFIT2, SFRP4 and ZWINT. A total of 18 DEGs detected comparing E2P4DHT vs. E2DHT were common for both PCOS and Ctrl, including genes involved in cytoskeleton and/or cell migratory properties (PLPPR4, LPAR1), and cell differentiation or proliferation (STC2, EZH2, HJURP, ANG, CENPN). The gene discussed is SFRP4; the disease is polycystic ovary syndrome.