The abnormally high levels of interleukin-8 (> 10 pg/ml) were associated with higher initial rates of clot growth with a median of 54.4 μm/min (IQR 51.3; 58.8) versus 49.2 μm/min (IQR 43.5; 52.5; p < 0.005) when interleukin-8 was normal (< 10 pg/ml), suggesting inflammation-induced hypercoagulability with a risk of immunothrombosis as a result of generalized activation of IL-8-producing innate immune cells. The gene discussed is CXCL8; the disease is thrombophilia.