The results obtained indicate that platelets are involved in the pathogenesis of COVID-19 and undergo definitive, yet moderate, alterations, both quantitative (mild thrombocytopenia) and qualitative (surface exposure of phosphatidylserine, expression and secretion of P-selectin, reduced expression of active integrin αIIbβ3 in response to stimulation, and morphological signs of cell activation). Here, SELP is linked to COVID-19.