Consistent with the notions that exceptionally broad H3K4me3 signature marks tumor-suppressor genes15 and that broad H3K27me3 marks oncogenes16, we observed that the ChIP-seq for H3K4me3 can cover up to 10 kb in the well-known tumor-suppressor gene, TP5321, and that broad H3K27me3 domains spanned up to 100 kb, which were present in the RSPO3 oncogenes22 (Fig. 1b). Here, RSPO3 is linked to neoplasm.