CTSG and acute leukemia: Furthermore, we selected these cell lines to test the DN4.99 TCR-T cells against a diverse selection of pathological features and levels of aggression, representing the acute leukemia spectrum: following intravenous (i.v.)injection into NOD.Cg-Prkdcscid IL- 2rgtm1Wjl/SzJ (NSG) mice, the THP-1 AML cell line, which is the least aggressive, generates liver myeloid sarcomas, while the NALM-6 B-ALL and MOLM-13 AML cell lines home to the bone marrow and are of relatively moderate and high aggressiveness, respectively22–24.