NALM-6-CD1c (5 × 105) cells were injected i.v. into NSG mice that, after tumor engraftment confirmed by their serum luciferase levels, were randomized into three groups and sub-lethally irradiated, followed 24 h later by the transfer i.v. of 1 × 107 DN4.99 TCR-T cells; 1 × 107 T cells transduced with the chimeric TCR from the CD1c-restricted T cell clone DL15A31, specific for an M. tuberculosis-derived lipid and completely unable to react in vitro against CD1c-expressing leukemia cells ± mLPA (Supplementary Fig. 4 and ref. 10); or vehicle alone (Fig. 8a). The gene discussed is CD1C; the disease is leukemia.