Notably, in the absence of high tumor burden, none of mice that received DN4.99 TCR-T cells showed weight loss, an effect of the xenogenic GvHD commonly observed upon transfer of human peptide-specific TCR that cross-react with mouse peptide–MHC complexes25, which was instead observed in mice receiving non-transduced T cells (Supplementary Fig. 3f). Here, HLA-C is linked to neoplasm.