We next assessed the breadth of reactivity of DN4.99 TCR-T cells against a panel of cell lines representing AML (THP-1, MOLM-13, K562), ALL (NALM-6, CCRF-SB, MOLT-4), and B lymphoblastoid cells (C1R), which expressed at different levels natural or transduced CD1c (Fig. 4a). Here, CD1C is linked to acute myeloid leukemia.