Having demonstrated potent CD1c-expressing leukemia-cell specific cytotoxicity of DN4.99 TCR-T cells, we next assessed DN4.99 TCR-T cell in vivo antitumor activity in mice injected with human acute leukemia-cell lines (THP-1, NALM-6, MOLM-13) stably transduced to express CD1c. The gene discussed is CD1C; the disease is acute leukemia.