While knockdown of CDK6, ZEB1, and Sec23a expression compromised mammosphere formation, tumor cell migration, and/or clustering of MDA-MB-231 cells (Fig. 3d, e and Supplementary Fig. 7a–f), only siCDK6 partially mimicked siICAM1 in inhibiting lung colonization of MDA-MB-231 cancer cells within 7 days after tail vein injection (Fig. 3f–h and Supplementary Fig. 7g–i). Here, SEC23A is linked to neoplasm.