Any context-dependent functions of ICAM1 in other subtypes and types of cancers, including melanoma and colon cancer cells25,49,50, breast cancer51–53, gastric cancer54, multiple myeloma55,56, and esophageal squamous cell carcinoma57 require deep mechanistic elucidation and comprehensive human tumor dataset validation. This evidence concerns the gene ICAM1 and malignant colon neoplasm.