To further detect whether the alterations in the chemokine profiles were critical in USP12-mediated control of tumour growth, we overexpressed Cxcl1 combined with or without Ccl2 into mouse lung tumour cells and found that LLC cells, when overexpressing Cxcl1, grew more rapidly than control cells (Fig. 3f). The gene discussed is CCL2; the disease is neoplasm.