We further analysed the expression patterns of these genes in human NSCLC using the TCGA-LUAD and GSE31210 databases and found that only USP12 was preferentially downregulated in both NSCLC tumours and tumourigenic KrasG12D;SV40-LT MEFs (Fig. 1a and Supplementary Fig. 1b). The gene discussed is USP12; the disease is neoplasm.