In vitro macrophage recruitment experiments showed that CM from tumour cells ectopically expressing USP12 but not USP12-C48S induced less migration of bone-marrow-derived macrophages (BMDMs) than the supernatant of control cells, whereas CM from LLC-shUSP12  cells exacerbated the BMDM migration (Supplementary Fig. 7a, b). Here, USP12 is linked to neoplasm.