GSDMD and breast carcinoma: By testing 108 cases of breast cancer tissues and 23 cases of para-cancerous benign tissues, the results showed the higher expression level of caspase-1, IL-1beta, and GSDMD were associated with the lower histopathologic grade of breast cancer, the smaller of tumor size, the lower possibility of metastasis, and the better the prognosis of breast cancer [63].