Moreover, the combination of KAT2A knockdown and abiraterone resulted in weaker staining intensities of PSA and Ki67 compared to those in the KAT2A knockdown-only group, indicating that the deletion of KAT2A enhanced the inhibitory effect of abiraterone on AR activity and the proliferation of C4-2-AbiR tumours (Fig. 6E). This evidence concerns the gene MKI67 and neoplasm.