In one of these studies conducted by Langhi C et al., they found that PCSK9 deficiency does not affect glucose-stimulated insulin secretion in mouse islets [24], while in the study conducted by Mbikay M et al., PCSK9-null mice showed hyperglycemia and signs of apoptosis in their pancreatic islets [26]. The gene discussed is PCSK9; the disease is Hyperglycemia.