Regarding the fact that PCSK9 is the main determinant factor in regulating plasma LDL cholesterol level and the genetic variants of PCSK9 may predispose to the incidence of T2DM, this study investigated the relationship between the PCSK9 rs615563 genotypes (a GOF allele) with the levels of circulating lipids and the incidence of diabetes on subsamples from a 5-year (2009–2014) cohort study. Here, PCSK9 is linked to diabetes mellitus.