RELA and hepatocellular carcinoma: Considering that both p65 and ARRB1 were upregulated in HCC, we further examined the activity of the p65 promoter and ARRB1 promoter after overexpressing normal active (WT), constitutively inactive (Ser536A), and constitutively active (Ser536E) NF-κBp65 in 293 T cells.