In contrast, subsequent studies suggested that IKKβ-deficient mice had markedly increased hepatocarcinogenesis after DEN treatment by compensatory proliferation, and hepatocyte-specific ablation of IKKγ/NEMO mice was found to spontaneously result in steatohepatitis followed by hepatocellular carcinoma [26, 29, 30]. This evidence concerns the gene IKBKG and hepatocellular carcinoma.