ARRB1 and hepatocellular carcinoma: However, a recent view of the GPCR field has demonstrated that GPCR signalling can be directly transduced through ARRB1 and that the translocation of ARRB1 to the nucleus enhances NF-κB activity [38–40], consistent with our findings that overexpression of ARRB1 in HCC cell lines increases the level of p65 phosphorylation and promotes p65 translocation into the nucleus.