Regarding parental carriers that are heterozygous for the variant c.335dupG (p.Cys112Trpfs*11) in the SOD1 gene, we still cannot say anything about the future risk of developing a neurodegenerative disease, and they need long-term clinical follow-up to early detect neurological manifestations related to ALS. The gene discussed is SOD1; the disease is neurodegenerative disease.