SOD1 and amyotrophic lateral sclerosis: neuron disorder with undoubtful upper and lower motor neuron involvement demonstrated by clinical examination, and corroborated by neurophysiological and muscle pathological studies that fulfills all the recently proposed diagnostic criteria for ALS with the same homozygous pathogenic variant in SOD1 gene reported by Andersen et al., and Park et al. allowing us to conclude that the cases presented by these authors, and the new additional patients reported in this study represent a very early infantile-onset ALS.