SOD1 and amyotrophic lateral sclerosis: Recently, Andersen et al. [5] and Park et al. [6] reported independently two Afghan patients with a severe neuromuscular disorder characterized by progressive motor neuron disease with hypotonia, spastic tetraplegia and loss of motor function due to SOD1 homozygous biallelic loss of function truncating mutations with no family history of ALS and concluded that this disorder is distinct from SOD1 related ALS and constitutes a new clinical entity [5, 6].