In HFD/DSS mice (versus HFD/DSS/HE mice), HE reduced RAGE activation at both RNA (by 1.8-fold) and protein (by 1.4-fold); this was paralleled by a decrease in the downstream factor NF-κB by 1.3-fold in HFD/DSS/HE mice. The gene discussed is AGER; the disease is hereditary elliptocytosis.