BCL2 and neoplasm: CSNP-mediated Cur and siCCAT1 co-delivery could effectively silence CCAT1 and achieve a synergistic effect, thereby increasing Bcl-2-mediated apoptosis of HT-29 cells, inhibiting EMT-mediated migration of HT-29 cells, and triggering conspicuous anti-tumor efficacy in vivo through combinational therapy with good biocompatibility during the treatment.