CASP3 and cancer: indicated that silencing of CCAT1 brought out the regulation of G0/G1 arrest markers, Caspase-3 and B-cell lymphoma-2 (Bcl-2), p16, p21 and p27, and pro-apoptotic factors, which showed that knockdown of CCAT1 could suppress cancer cell proliferation by the motivation of G0/G1 arrest and apoptosis [19].