We queried the expression profile of DNA methyltransferases DNMT3A and DNMT3B, which have been described to be related to CpG island methylation in GC, in the StarBase Pan-cancer platform (http://starbase.sysu.edu.cn/panCancer.php), and we observed that the expression of both was elevated in GC (Fig. 7A). This evidence concerns the gene DNMT3A and cancer.