Older age [1, 2, 6, 7], hypertension [1, 2, 7], diabetes mellitus [6], low total cholesterol [7, 8], chronic kidney disease (CKD) [9–14], presence of APOE4 [15], and use of antithrombotics [16] have been shown to be risk factors for CMBs in cohorts with stroke and in community-dwelling elderly individuals. The gene discussed is APOE; the disease is chronic kidney disease.