In all migraine cohorts with aura, 3 SNPs had P < 5 E-08 (rs77630941 in CUX1, rs146778855 in CDH18, and rs117608715 in NOL3) and 1 SNP (rs150592309 in PRAP1) were almost significant in the aura groups (P = 6.66 E-10, P = 1.21 E-08, P = 1.78 E-08, P = 8.88 E-08, respectively in Fig. 4A–D). This evidence concerns the gene CDH18 and migraine disorder.