ADIPOQ and cryohydrocytosis: As the 12-month-old mice is equivalent to 58-year-old men [42], and the mean age of our human cohort is 61.3 years, the association of TG levels with adiponectin levels in 12-month-old HCV core transgenic mice echoes the crucial role of TG in affecting adiponectin levels in CHC patients and suggests the potential impact of HCV core on adiponectin levels.