ADIPOQ and cryohydrocytosis: The HCV-associated factors for adiponectin might account for the decreasing trend of adiponectin levels, since low TG and high FIB-4 levels in CHC patients before viral clearance [8] lead to high baseline adiponectin levels; after viral clearance, reversal of hypotriglycemia and improved hepatic fibrosis [3, 8] cause decreased adiponectin levels.