At baseline, for all 427 CHC patients, male sex, estimated glomerular filtration rates (eGFRs) and levels of triglycerides (TG) were negatively, and levels of fibrosis-4 (FIB-4) were positively associated with adiponectin levels (Table 2); levels of BMI and TG and HCV genotype other than 1, 2 and 3 (non-HCV G123) were positively associated with HOMA-IR (Table 3). The gene discussed is ADIPOQ; the disease is cryohydrocytosis.