TARDBP and amyotrophic lateral sclerosis: Post-mortem tissue from ∼97% of individuals with ALS presents TDP-43 aggregates, and TDP-43 proteinopathy is also common in frontotemporal dementia (FTD), limbic-predominant age-related TDP-43 encephalopathy (LATE) and Alzheimer’s disease (Gao et al., 2019; Nelson et al., 2019).