As further insight into the regulated RNA network, we identified 136 mRNAs with PAS switches, four of which are associated with ALS or TDP-43 regulation, including the core stress granule protein G3BP1, which is essential for granule formation in response to specific stressors (Guillén-Boixet et al., 2020; Yang et al., 2020). Here, TARDBP is linked to amyotrophic lateral sclerosis.