We addressed this question by analyzing two abundant long non-coding RNAs (lncRNAs) that contain multiple binding regions with large numbers of iCLIP cDNAs: NEAT1 and MALAT1. These lncRNAs participate in cross-regulation with TDP-43 and are differentially bound in brain tissue from individuals with FTD (Modic et al., 2019; Nguyen et al., 2020; Tollervey et al., 2011), and NEAT1 has been found to influence the phase separation propensity of bound RBPs (Maharana et al., 2018). Here, TARDBP is linked to frontotemporal dementia.