Transcriptome-wide changes in RNA processing have been observed in post-mortem human tissue and in animal models of mutant TDP-43, and a decreased capacity of mutant TDP-43 to autoregulate its own expression has been observed in a mouse model of the Q331K ALS mutation, which increases the levels of TDP-43 protein (White et al., 2018), but the mechanism underpinning the impaired autoregulation remained unclear. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.