For SCN1A variants, mean of log10 FGF‐21 level of DS patients with missense variants (Mean ± SEM: 2.439 ± 0.3741; n = 10) has no significant difference from those with truncated variants (Mean ± SEM: 2.395 ± 0.2249; n = 12) by unpaired t‐test (two‐tailed P value = .916) (Figure 2C). This evidence concerns the gene FGF21 and Dravet syndrome.