For more detailed analysis and further verification of the MMBSearch results, we chose to focus on lung adenocarcinomas based on our observation that MMB-TI events were significantly elevated in lung adenocarcinoma samples from TCGA, and because it was recently demonstrated that this type of cancer frequently accumulates single-stranded DNA (ssDNA) and also likely uses BIR for DSB repair (33,34), which can enable MMBIR. The gene discussed is KCNJ11; the disease is cancer.