In addition, the stimulation with CpG and/or the infection with PUUV or SeV all induced, as compared to mock-infected B cells, an approximately two-fold increase in the secretion of soluble IgA (~1–2 vs. 0.8 μg/ml), IgM (1–1.5 vs. 0.75 μg/ml) and IgG (~1.5 vs. 0.75 μg/ml). The gene discussed is CD40LG; the disease is infection.