To demonstrate the application of established mouse model in the research on therapeutics for COVID-19, AAV/hACE2 mice were employed to examine the efficacy of an antibody cocktail that comprises two chimeric anti-SARS-CoV-2 spike RBD monoclonal antibodies (RBD-chAb-28 and RBD-chAb-51). The gene discussed is CHMP5; the disease is COVID-19.