IL6 and COVID-19: Subsequently, to further determine whether SARS-CoV-2 infection in AAV/hACE2 mice model could also induce proinflammatory mediators as shown in severe COVID-19 patients [4,59,60], RNA levels of TNF-α, IL-1β, IL-6, CCL2, and CXCL10 in mice lung homogenates were measured.