We examined the relative levels of the ISGs Oasl2, Mx1, and Ifit1 in the placenta because of their known relevance to mouse (23, 44, –, 47) and nonhuman primate (48) models of ZIKV infection, broad-spectrum antiviral functions (49, –, 53), contributions to placental pathology (42, 54), and general involvement in the success of human pregnancies (30, 39, 55). This evidence concerns the gene IFIT1 and Zika virus infectious disease.