We examined the relative levels of the ISGs Oasl2, Mx1, and Ifit1 in the placenta because of their known relevance to mouse (23, 44, –, 47) and nonhuman primate (48) models of ZIKV infection, broad-spectrum antiviral functions (49, –, 53), contributions to placental pathology (42, 54), and general involvement in the success of human pregnancies (30, 39, 55). The gene discussed is MX1; the disease is Zika virus infectious disease.