TFAM and Mitochondrial myopathy: The rate of phosphocreatine recovery was markedly decreased and the 10-min recovery period was not long enough for a complete recovery in Tfam KO mice, which is in agreement with the slow phosphocreatine recovery kinetics commonly reported in patients with mitochondrial myopathies (Barbiroli et al., 1997; Bendahan et al., 1992; Kornblum et al., 2005; Moller et al., 2005; Radda et al., 1982; Taylor et al., 1994).