AXIN2 and cancer: Mutations and single nucleotide polymorphism (SNP) in some genes, such as axis inhibition protein 2 (AXIN2),12 muscle segment homeobox 1 (MSX1),13 paired box gene 9 (PAX9),14 and wingless type MMTV integration site family, member 10A (WNT10A)15 have been related with dental agenesis and interestingly, mutations in these genes may be connected with many types of cancers.16