Mutations and single nucleotide polymorphism (SNP) in some genes, such as axis inhibition protein 2 (AXIN2),12 muscle segment homeobox 1 (MSX1),13 paired box gene 9 (PAX9),14 and wingless type MMTV integration site family, member 10A (WNT10A)15 have been related with dental agenesis and interestingly, mutations in these genes may be connected with many types of cancers.16 Here, MSX1 is linked to cancer.