The susceptibility of STAT1 KO mice to development of IBD is consistent with the observation that human patients carrying a hypomorphic allele of STAT1 develop symptoms of colitis (Thoeni et al., 2015; Sharfe et al., 2014) and that many genes associated with IBD susceptibility are related to the IFN pathway (Jostins et al., 2012). Here, STAT1 is linked to colitis.