Ingestion of regular small meals with concomitant administration ofrapid acting insulin and frequent glucose monitoring is a commonly adopted approach,however this poses a significant management burden for affected individuals and canbe difficult to maintain.2 Addition of insulin for fat and protein content, and for those on insulinpump therapy, dual-wave boluses or frequent small boluses to match glycemic excursions28 are strategies that have been shown to effectively reduce post-prandialglucose excursions but are associated with high rates of hypoglycemia.29,30. The gene discussed is INS; the disease is Hypoglycemia.