SPI1 and hepatocellular carcinoma: HGF is highly expressed in the liver microenvironment and can facilitate tumor growth.[43] Moreover, the HGF/c‐Met pathway is one of the most important RTK pathways in both the liver and advanced hepatocellular carcinoma.[44] Recombinant HGF did not affect PU.1 expression (Figure 6B) but significantly enhanced PU.1 phosphorylation in HT29 and CRC57 cells, which was abrogated by the c‐Met inhibitor PHA665752 (Figure 6C).