For example, Notch receptor can act both as oncogene or tumor suppressor in different cancer types.[50] TGF‐β functions as tumor suppressor in early‐stage CRC but promotes metastasis and immune evasion in late stage and metastases.[51, 52] Similarly, DPP4 seems to play dual roles in different cancer types and highlights the opposing forces between cancer cell intrinsic mechanisms and the microenvironment. This evidence concerns the gene TGFB1 and colorectal carcinoma.