SPI1 and colorectal carcinoma: PU.1 activation requires phosphorylation to enhance its DNA binding and co‐factor recruitment.[42] Pathway analysis based on liver metastases‐enriched open chromatin regions identified by ATAC‐seq showed that receptor tyrosine kinase (RTK) pathways were consistently activated in liver metastases of mice injected with each of the four tested CRC cell lines (Figure6A and Figure S8, Supporting Information).