Previous reports showed that inhibition of DPP4 induced breast and prostate cancer metastasis via the CXCL12/CXCR4/mTOR axis and epithelial‐to‐mesenchymal transition (EMT).[48, 49] This highlights the importance of context, which includes cancer type, stage, and microenvironment. This evidence concerns the gene CXCR4 and Familial prostate cancer.