CXCL6 and colorectal carcinoma: DPP4 has been shown to truncate the neutrophil chemoattractants CXCL6 and CXCL10.[34, 35, 36, 37] NSG mice lack mature T cells, B cells, and NK cells and have defective dendritic cells and macrophages, but their neutrophils are intact.[38] We analyzed neutrophil accumulation in the primary CRC and liver metastases in orthopotic injection mouse model, finding that knocking out DPP4 in CRC cells significantly increased neutrophil accumulation in both primary CRC and liver metastases (Figure S7A–C, Supporting Information).