HGF and colorectal carcinoma: For instance, DPP4 expression has been associated with poor CRC prognosis,[46] and a recent epidemiology study revealed that diabetic patients with CRC who were treated with DPP4 inhibitors had a statistically significant survival advantage.[47] The HGF/PU.1/DPP4 axis is unlikely the only major chromatin remodeling axis in CRC liver metastasis, as PU.1 have other downstream targets while the DPP4 enhancers have other upstream regulators.