CXCL8 and atherosclerosis: The proinflammatory transcription factor Irf1 is known to play a role in regulating several proteins involved in atherosclerosis‐related inflammation, such as Retinoic Acid‐Inducible Gene I (RIG‐I) and Interleukin 8 (Il‐8).[24] Sub1 is phosphorylated by the protein kinase Ck2, which is induced by LPS and is associated with proinflammatory downstream gene expression in macrophages.[25] Moreover, the combination of Sub1 and Ck2 is necessary for downstream promoter element (DPE)‐dependent transcription of Irf1.