TSC1 and lymphangioleiomyomatosis: LAM can occur sporadically (S‐LAM) or in presence of tuberous sclerosis complex (TSC‐LAM), an autosomal‐dominant multisystem disorder caused by germline or mosaic loss‐of‐function mutations in the tumor suppressor genes TSC1 and TSC2 (Crino et al, 2006; Giannikou et al, 2016).