In this context, GBM cells are highly dependent on cholesterol supply for survival5 and rely on exogenous cholesterol uptake, mediated by the low-density lipoprotein receptor (LDLR).6 Indeed, LDLR is expressed in GBM and its upregulation correlates with tumor progression and drug resistance.5,7,8. This evidence concerns the gene VLDLR and glioblastoma.