To investigate whether mApoE-LIPs could be exploited to target the tumor stem cell subpopulation, 3 GSC lines (IDH1/2 wt) established from patient surgical samples were selected, based on their responsiveness to DOXO: cells with high (GSC1) or moderate (GSC2) sensitivity to DOXO and nonresponder cells (GSC3). Here, IDH1 is linked to neoplasm.