CD8A and hepatocellular carcinoma: To support the rationale for using blood-derived MAIT cells for immunotherapy against liver cancer, we analysed the similarities between T cells residing in both tissue compartments using publicly available single-cell and bulk transcriptome datasets.[37], [38], [39] Conventional CD8+ T cells and MAIT cells derived from patients with HCC were labelled according to their compartment of origin (matched blood, normal liver tissue, and HCC) and analysed by Uniform Manifold Approximation and Projection (UMAP) dimension reduction (Fig. 1A).