BRAF and colorectal carcinoma: Participants in the highest quartile of smoking pack-years had nearly a 2-fold risk for CRC if they had BRAF-mut (OR = 1.92, 95% CI = 1.58 to 2.33) or CIMP+ tumors (OR = 1.90, 95% CI = 1.60 to 2.26), compared with nonsmokers, respectively.